Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications

Seda Özdikmenli Tepeli; Kahraman Selvi

doi:10.29002/asujse.1960299

EN TR

Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications

Öz

The growing global threat of antibiotic resistance has necessitated research into alternative or complementary treatment methods. This study aims to demonstrate the current potential of bacteriophages (phages) in both clinical and industrial applications and to evaluate examples of their applications. Within the scope of the study, current scientific articles, clinical case reports, and legal regulations related to the subject were comprehensively reviewed. The analysis indicates that phage therapy shows promising results, particularly for treating multidrug-resistant bacterial infections. Success rates in personalized treatments and “compassionate use” programs were above 50%, with no serious side effects reported. In the industrial sector, phages stand out as effective “biocontrol agents” for food safety and aquaculture, controlling pathogens such as Salmonella, Listeria, E. coli, and Vibrio. In conclusion, phages offer a powerful alternative to traditional antimicrobials due to their specificity and environmental friendliness. However, for this potential to be realized on a global scale, regulatory uncertainties must be resolved and production standardization achieved.

Anahtar Kelimeler

Antibiyotik Direnç Çağında Bakteriyofajlar: Terapötik ve Endüstriyel Uygulamalar

Öz

Antibiyotik direncinin küresel düzeyde artan tehdidi, alternatif veya tamamlayıcı tedavi yöntemlerinin araştırılmasını zorunlu kılmıştır. Bu çalışmanın amacı; bakteriyofajların (fajların) hem klinik hem de endüstriyel alanlardaki güncel potansiyelini ortaya koymak ve uygulama örneklerini değerlendirmektir. Çalışma kapsamında, konuyla ilgili güncel bilimsel makaleler, klinik vaka raporları ve yasal düzenlemeler kapsamlı bir şekilde taranmıştır. Yapılan incelemeler sonucunda; faj terapisinin, özellikle çoklu ilaca dirençli bakteriyel enfeksiyonların tedavisinde umut verici sonuçlar gösterdiği belirlenmiştir. Kişiselleştirilmiş tedavilerde ve "insani amaçlı ilaca erken erişim" (compassionate use) programlarında başarı oranlarının %50’nin üzerinde olduğu ve ciddi bir yan etki bildirilmediği görülmüştür. Endüstriyel alanda ise fajlar; Salmonella, Listeria, E. coli ve Vibrio gibi patojenlerin kontrolünde, gıda güvenliği ve su ürünleri yetiştiriciliğinde etkili "biyokontrol ajanları" olarak öne çıkmaktadır. Sonuç olarak fajlar; özgüllükleri ve çevre dostu yapılarıyla geleneksel antimikrobiyallere güçlü bir alternatif sunmaktadır. Ancak, bu potansiyelin küresel ölçekte yaygınlaşması için yasal düzenleyici belirsizliklerin giderilmesi ve üretim standardizasyonunun sağlanması gerekmektedir.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Mikrobiyoloji (Diğer)

Bölüm

Derleme

Yazarlar

Seda Özdikmenli Tepeli ^*
0000-0002-1613-5917
Türkiye

Kahraman Selvi
0000-0002-6974-4441
Türkiye

Erken Görünüm Tarihi

21 Eylül 2026

Yayımlanma Tarihi

-

Gönderilme Tarihi

30 Mayıs 2026

Kabul Tarihi

4 Eylül 2026

Yayımlandığı Sayı

Yıl 2026 Sayı: Advanced Online Publication

DOI

https://doi.org/10.29002/asujse.1960299

IZ

https://izlik.org/JA38SJ33AF

Kaynak Göster

RIS / Bibtex

APA

Özdikmenli Tepeli, S., & Selvi, K. (2026). Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications. Aksaray University Journal of Science and Engineering, Advanced Online Publication, 102-110. https://doi.org/10.29002/asujse.1960299

AMA

1.Özdikmenli Tepeli S, Selvi K. Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications. Aksaray J. Sci. Eng. 2026;(Advanced Online Publication):102-110. doi:10.29002/asujse.1960299

Chicago

Özdikmenli Tepeli, Seda, ve Kahraman Selvi. 2026. “Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications”. Aksaray University Journal of Science and Engineering, sy Advanced Online Publication: 102-10. https://doi.org/10.29002/asujse.1960299.

EndNote

Özdikmenli Tepeli S, Selvi K (01 Eylül 2026) Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications. Aksaray University Journal of Science and Engineering Advanced Online Publication 102–110.

IEEE

[1]S. Özdikmenli Tepeli ve K. Selvi, “Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications”, Aksaray J. Sci. Eng., sy Advanced Online Publication, ss. 102–110, Eyl. 2026, doi: 10.29002/asujse.1960299.

ISNAD

Özdikmenli Tepeli, Seda - Selvi, Kahraman. “Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications”. Aksaray University Journal of Science and Engineering. Advanced Online Publication (01 Eylül 2026): 102-110. https://doi.org/10.29002/asujse.1960299.

JAMA

1.Özdikmenli Tepeli S, Selvi K. Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications. Aksaray J. Sci. Eng. 2026;:102–110.

MLA

Özdikmenli Tepeli, Seda, ve Kahraman Selvi. “Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications”. Aksaray University Journal of Science and Engineering, sy Advanced Online Publication, Eylül 2026, ss. 102-10, doi:10.29002/asujse.1960299.

Vancouver

1.Seda Özdikmenli Tepeli, Kahraman Selvi. Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications. Aksaray J. Sci. Eng. 01 Eylül 2026;(Advanced Online Publication):102-10. doi:10.29002/asujse.1960299