Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications

Seda Özdikmenli Tepeli; Kahraman Selvi

doi:10.29002/asujse.1960299

EN TR

Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications

Abstract

The growing global threat of antibiotic resistance has necessitated research into alternative or complementary treatment methods. This study aims to demonstrate the current potential of bacteriophages (phages) in both clinical and industrial applications and to evaluate examples of their applications. Within the scope of the study, current scientific articles, clinical case reports, and legal regulations related to the subject were comprehensively reviewed. The analysis indicates that phage therapy shows promising results, particularly for treating multidrug-resistant bacterial infections. Success rates in personalized treatments and “compassionate use” programs were above 50%, with no serious side effects reported. In the industrial sector, phages stand out as effective “biocontrol agents” for food safety and aquaculture, controlling pathogens such as Salmonella, Listeria, E. coli, and Vibrio. In conclusion, phages offer a powerful alternative to traditional antimicrobials due to their specificity and environmental friendliness. However, for this potential to be realized on a global scale, regulatory uncertainties must be resolved and production standardization achieved.

Keywords

Antibiyotik Direnç Çağında Bakteriyofajlar: Terapötik ve Endüstriyel Uygulamalar

Abstract

Antibiyotik direncinin küresel düzeyde artan tehdidi, alternatif veya tamamlayıcı tedavi yöntemlerinin araştırılmasını zorunlu kılmıştır. Bu çalışmanın amacı; bakteriyofajların (fajların) hem klinik hem de endüstriyel alanlardaki güncel potansiyelini ortaya koymak ve uygulama örneklerini değerlendirmektir. Çalışma kapsamında, konuyla ilgili güncel bilimsel makaleler, klinik vaka raporları ve yasal düzenlemeler kapsamlı bir şekilde taranmıştır. Yapılan incelemeler sonucunda; faj terapisinin, özellikle çoklu ilaca dirençli bakteriyel enfeksiyonların tedavisinde umut verici sonuçlar gösterdiği belirlenmiştir. Kişiselleştirilmiş tedavilerde ve "insani amaçlı ilaca erken erişim" (compassionate use) programlarında başarı oranlarının %50’nin üzerinde olduğu ve ciddi bir yan etki bildirilmediği görülmüştür. Endüstriyel alanda ise fajlar; Salmonella, Listeria, E. coli ve Vibrio gibi patojenlerin kontrolünde, gıda güvenliği ve su ürünleri yetiştiriciliğinde etkili "biyokontrol ajanları" olarak öne çıkmaktadır. Sonuç olarak fajlar; özgüllükleri ve çevre dostu yapılarıyla geleneksel antimikrobiyallere güçlü bir alternatif sunmaktadır. Ancak, bu potansiyelin küresel ölçekte yaygınlaşması için yasal düzenleyici belirsizliklerin giderilmesi ve üretim standardizasyonunun sağlanması gerekmektedir.

Keywords

References

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Details

Primary Language

English

Subjects

Microbiology (Other)

Journal Section

Review

Authors

Seda Özdikmenli Tepeli ^*
0000-0002-1613-5917
Türkiye

Kahraman Selvi
0000-0002-6974-4441
Türkiye

Early Pub Date

September 21, 2026

Publication Date

-

Submission Date

May 30, 2026

Acceptance Date

September 4, 2026

Published in Issue

Year 2026 Number: Advanced Online Publication

DOI

https://doi.org/10.29002/asujse.1960299

IZ

https://izlik.org/JA38SJ33AF

Cite

RIS / Bibtex

APA

Özdikmenli Tepeli, S., & Selvi, K. (2026). Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications. Aksaray University Journal of Science and Engineering, Advanced Online Publication, 102-110. https://doi.org/10.29002/asujse.1960299

AMA

1.Özdikmenli Tepeli S, Selvi K. Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications. Aksaray J. Sci. Eng. 2026;(Advanced Online Publication):102-110. doi:10.29002/asujse.1960299

Chicago

Özdikmenli Tepeli, Seda, and Kahraman Selvi. 2026. “Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications”. Aksaray University Journal of Science and Engineering, no. Advanced Online Publication: 102-10. https://doi.org/10.29002/asujse.1960299.

EndNote

Özdikmenli Tepeli S, Selvi K (September 1, 2026) Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications. Aksaray University Journal of Science and Engineering Advanced Online Publication 102–110.

IEEE

[1]S. Özdikmenli Tepeli and K. Selvi, “Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications”, Aksaray J. Sci. Eng., no. Advanced Online Publication, pp. 102–110, Sept. 2026, doi: 10.29002/asujse.1960299.

ISNAD

Özdikmenli Tepeli, Seda - Selvi, Kahraman. “Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications”. Aksaray University Journal of Science and Engineering. Advanced Online Publication (September 1, 2026): 102-110. https://doi.org/10.29002/asujse.1960299.

JAMA

1.Özdikmenli Tepeli S, Selvi K. Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications. Aksaray J. Sci. Eng. 2026;:102–110.

MLA

Özdikmenli Tepeli, Seda, and Kahraman Selvi. “Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications”. Aksaray University Journal of Science and Engineering, no. Advanced Online Publication, Sept. 2026, pp. 102-10, doi:10.29002/asujse.1960299.

Vancouver

1.Seda Özdikmenli Tepeli, Kahraman Selvi. Bacteriophages in the Age of Antibiotic Resistance: Therapeutic and Industrial Applications. Aksaray J. Sci. Eng. 2026 Sep. 1;(Advanced Online Publication):102-10. doi:10.29002/asujse.1960299