Abstract
Mammography
and standard breast imaging devices in the hospital are not enough an accurate
diagnosis of breast cancer especially over the 40 years old and overweight
women. The spatial resolution of the scintillation detector system is a highly
important parameter for nuclear medical imaging. GATE simulation program, based
on GEANT4, is used for the investigation of the SPECT system with different
scintillations which are commonly used in the imaging device. Medical images
for the point source are obtained by ImageJ software and image properties such
as spatial resolution and mean grey values are compared for the several
scintillations. This research shows that the spatial resolution value for
GAGG(Ce), relatively new scintillation material, is very close to SrI which is
one of the expensive scintillators. NaI, LaBr and CeBr are extremely
hygroscopic and not easy to be packaging with a specific shape. Therefore,
GAGG(Ce) are found to be encouraging result to be a part of the novel medical
image device. This study also shows how important using collimator in front of
the scintillation material for obtaining a meaningful image and how improved
the image quality using the array scintillator instead of one single block.
There is not any research regarding medical imaging obtained by GAGG(Ce)
scintillation material in GEANT4 simulation, so this research data presented
are the first of their kind.
References
- [1] WHO, International Agency for Research on Cancer, Press Relase, No:263, 2018.
- [2] M.K. O’Connor, H. Li, D.J. Rhodes, C.B. Hruska, C.B. Clancy, R.J. Vetter “Comparison of radiation exposure and associated radiation-induced cancer risks from mammography and molecular imaging of the breast”, Medical Physics 37 (12):6187-6198, 2010.
- [3] G. Sadikoglu, A. Ozcakır, F. Dogan, S. Gokgoz, N. Bilgel “Mammography Utilization among Turkish Women”, Asian Pacific Journal of Cancer Prevention, 11:377-381, 2010.
- [4] B. D. Pettit, N. Calonge, M.L. LeFevre, B.M. Melnyk, T.J. Wilt, J.S. Schwartz “Breast Cancer Screening: Science to Recommendation”, Radiology, 256(1):8-14, 2010.
- [5] P. H. Niloff, N.M. Sheiner “False-negative mammograms in patients with breast cancer”, CanJ Surg, 24 (50-52), 1981.
- [6] M. A. Alnafea “Detection and Diagnosis of Breast Diseases”, INTECH, Chapter 1, 2017.
- [7] C.B. Hruska “Molecular Breast Imaging for Screening in Dense Breasts: State of the Art and Future Directions”, American Journal of Roentgenology, 208(2):275-283, 2017.
- [8] E. A. Sickles “Mammographic features of early breast cancer.” Am J Roentgenol: 143: (461-464), 1984.
- [9] F.B. Rachel, K.H. Michener, G.Zawistowski "Approaches to Improving Breast Cancer Diagnosis Using a High Resolution, Breast Specific Gamma Camera”, Physica Medica, 21(1):17-21, 2006.
- [10] C. Balleyguier, M. Cousin, A. Dunant, M. Attard, S. Delaloge, J. Arfi-Rouche “Patient-assisted compression helps for image quality reduction dose and improves patient experience in mammography”, European Journal of Cancer, 103(137-142), 2018.
- [11] M. I. Feldman, K. Ching, C. Andaz, P. Borgen, J. Kalowitz “Breast-Specific Gamma Imaging: Early Experience, Benefits, and Challenges”, Contemporary Diagnostic Radiology, 32(24):1-5, 2009.
- [12] M. Demir, “Nükleer Tıp Fiziği ve Klinik Uygulamaları” Bolüm 2, İ.Ü. Cerrahpaşa Tıp Fakültesi Nükleer Tıp Anabilim Dalı Öğretim Üyesi, Pozitron Teknik Hizmetler İç ve Dış Tic. San. Ltd. Şti. 2008.
- [13] I. F. Castro “Small Field of View Gamma Cameras”, Doctoral Program Eng. Physics, University of Aveiro,2010.
- [14] S. Li, Q. Zhang, Z. Xie, Q. Liu, B. Xu, K. Yang, C. Li, Q. Ren “GATE simulation of a LYSO-based SPECT imager: Validation and detector optimization”, Nuclear Instruments and Methods in Physics Research A, 773:21-26, 2015.
- [15] Open Gate Collaboration “Users Guide V8.0 From Wiki OpenGATE”. Accessed February 2018, http://www.opengatecollaboration.org/sites/default/files/GATE-UsersGuideV8.0.pdf
- [16] Advatech - Radiation Detection/Imaging and Photonics “Scintillation Crystals – Properties”. Accessed December 2018, https://www.advatech-uk.co.uk/gagg_ce.html
- [17] T. Ferreira and W. Rasband, 2012. “ImageJ User Guide ImageJ/Fiji 1.46”. Accessed January 20, 2018, https://imagej.nih.gov/ij/docs/guide/user-guide.pdf
Abstract
Hastanedeki mamografi ve standart meme görüntüleme
cihazları, özellikle 40 yaş üstü ve kilolu kadınların meme kanseri teşhisi için
yeterli değildir. Sintilasyon dedektör sisteminin uzaysal çözünürlüğü, nükleer
tıbbi görüntüleme için son derece önemli bir parametredir. GEANT4 tabanlı çalışan GATE
simülasyon programı, görüntüleme cihazlarında kullanılan farklı sintilatörlü
SPECT sisteminin araştırılması için kullanıldı. Nokta kaynağın medikal
görüntüsü ImageJ yazılımı ile elde edildi ve çeşitli sintilatörler için uzaysal
çözünürlük ve ortalama gri değerler gibi görüntü özellikleri karşılaştırıldı.
Bu araştırma, nispeten yeni bir sintilasyon malzemesi olan GAGG(Ce) için
uzaysal çözünürlük değerinin, pahalı sintilatörlerden biri olan SrI'ye çok
yakın olduğunu göstermektedir. NaI, LaBr ve CeBr gibi sintilatörler son derece
nemçeker ve istenilen şekilde ambalajlanarak kullanılması kolay olmayan
malzemelerdir. Bu nedenle, GAGG(Ce), yeni tıbbi görüntüleme cihazının bir
parçası olabilmesi açısından gelecek vaat etmektedir. Bu çalışma aynı zamanda
anlamlı bir görüntü elde etmek için sintilatörün önünde kolimatör kullanmanın
ne kadar önemli olduğunu ve tek bir blok yerine dizi sintilatörler kümesi
kullanılarak görüntü kalitesinin nasıl değiştiğini de göstermektedir. GAGG(Ce)
sintilasyon materyali hakkında daha önceden GEANT4 simülasyonu ile yapılmış
medikal görüntüleme üzerine sunulan bir çalışma olmadığından dolayı bu
araştırma verileri türünün ilk örneğidir.
References
- [1] WHO, International Agency for Research on Cancer, Press Relase, No:263, 2018.
- [2] M.K. O’Connor, H. Li, D.J. Rhodes, C.B. Hruska, C.B. Clancy, R.J. Vetter “Comparison of radiation exposure and associated radiation-induced cancer risks from mammography and molecular imaging of the breast”, Medical Physics 37 (12):6187-6198, 2010.
- [3] G. Sadikoglu, A. Ozcakır, F. Dogan, S. Gokgoz, N. Bilgel “Mammography Utilization among Turkish Women”, Asian Pacific Journal of Cancer Prevention, 11:377-381, 2010.
- [4] B. D. Pettit, N. Calonge, M.L. LeFevre, B.M. Melnyk, T.J. Wilt, J.S. Schwartz “Breast Cancer Screening: Science to Recommendation”, Radiology, 256(1):8-14, 2010.
- [5] P. H. Niloff, N.M. Sheiner “False-negative mammograms in patients with breast cancer”, CanJ Surg, 24 (50-52), 1981.
- [6] M. A. Alnafea “Detection and Diagnosis of Breast Diseases”, INTECH, Chapter 1, 2017.
- [7] C.B. Hruska “Molecular Breast Imaging for Screening in Dense Breasts: State of the Art and Future Directions”, American Journal of Roentgenology, 208(2):275-283, 2017.
- [8] E. A. Sickles “Mammographic features of early breast cancer.” Am J Roentgenol: 143: (461-464), 1984.
- [9] F.B. Rachel, K.H. Michener, G.Zawistowski "Approaches to Improving Breast Cancer Diagnosis Using a High Resolution, Breast Specific Gamma Camera”, Physica Medica, 21(1):17-21, 2006.
- [10] C. Balleyguier, M. Cousin, A. Dunant, M. Attard, S. Delaloge, J. Arfi-Rouche “Patient-assisted compression helps for image quality reduction dose and improves patient experience in mammography”, European Journal of Cancer, 103(137-142), 2018.
- [11] M. I. Feldman, K. Ching, C. Andaz, P. Borgen, J. Kalowitz “Breast-Specific Gamma Imaging: Early Experience, Benefits, and Challenges”, Contemporary Diagnostic Radiology, 32(24):1-5, 2009.
- [12] M. Demir, “Nükleer Tıp Fiziği ve Klinik Uygulamaları” Bolüm 2, İ.Ü. Cerrahpaşa Tıp Fakültesi Nükleer Tıp Anabilim Dalı Öğretim Üyesi, Pozitron Teknik Hizmetler İç ve Dış Tic. San. Ltd. Şti. 2008.
- [13] I. F. Castro “Small Field of View Gamma Cameras”, Doctoral Program Eng. Physics, University of Aveiro,2010.
- [14] S. Li, Q. Zhang, Z. Xie, Q. Liu, B. Xu, K. Yang, C. Li, Q. Ren “GATE simulation of a LYSO-based SPECT imager: Validation and detector optimization”, Nuclear Instruments and Methods in Physics Research A, 773:21-26, 2015.
- [15] Open Gate Collaboration “Users Guide V8.0 From Wiki OpenGATE”. Accessed February 2018, http://www.opengatecollaboration.org/sites/default/files/GATE-UsersGuideV8.0.pdf
- [16] Advatech - Radiation Detection/Imaging and Photonics “Scintillation Crystals – Properties”. Accessed December 2018, https://www.advatech-uk.co.uk/gagg_ce.html
- [17] T. Ferreira and W. Rasband, 2012. “ImageJ User Guide ImageJ/Fiji 1.46”. Accessed January 20, 2018, https://imagej.nih.gov/ij/docs/guide/user-guide.pdf
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 30, 2019 |
| Submission Date | November 19, 2019 |
| Acceptance Date | November 30, 2019 |
| Published in Issue | Year 2019 |
Aksaray J. Sci. Eng. | e-ISSN: 2587-1277 | Period: Biannually | Founded: 2017 | Publisher: Aksaray University | https://asujse.aksaray.edu.tr
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