Naringenin Baskılanmış Kriyojel Membranların Hazırlanması ve Adsorpsiyon Davranışlarının İncelenmesi
Öz
Naringenin önemli terapötik (tedavi edici) etkileri olan flavonoid sınıfından bir flavanondur. Yurt dışında fazlaca çalışılmış bir bileşik olan naringenin ülkemizde çok fazla dikkat çekmemiş olduğu düşünülmektedir. Yaygın şekilde bitkilerde bulunan bu naringenin molekülüne dikkat çekmek için yeni bir yöntem olan moleküler baskılama yöntemi kullanılarak naringenin baskılanmış kriyojeller sentezlenmiştir. Elementel analiz, termogravimetrik analiz ve şişme testleri gibi karakterizasyon çalışmaları ile birlikte adsorpsiyon ve seçicilik testleri de gerçekleştirilmiştir. Elde edilen bulgulardan bazıları aşağıda özetlenmiştir: Naringenin baskılanmış polimerlerde bozunma sıcaklığı 1,7 °C kadar yükselmiştir. Naringenin baskılanmış polimerdeki naringenin miktarı baskılanmamışa oranla %16,36’lık oranda yüksek bulunmuştur. MIP ve NIP için şişme değerleri sırasıyla %850 %967 olarak hesaplanmıştır.
Anahtar Kelimeler
Naringenin Moleküler baskılanmış polimer Naringenin saflaştırılması
Destekleyen Kurum
Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK
Proje Numarası
121Z173
Teşekkür
Bu çalışma Türkiye Bilimsel ve Teknolojik Araştırma Kurumu tarafından desteklenmiştir (Hibe Numarası: 121Z173). Bu destek için TÜBİTAK'a çok teşekkür ederiz.
Kaynakça
- Acet Ö, Noma SAA, Acet BÖ, Dikici E, Osman B. Odabaşı M. 2023. A rational approach for 3D recognition and removal of L-asparagine via molecularly imprinted membranes. J Pharmac Biomedic Analysis, 226: 115250.
- Acet Ö, Odabaşı M. 2022. Detection of N-hexanoyl-L-homoserine lactone via MIP-based QCM sensor: preparation and characterization. Polymer Bul, 80: 6657-6674.
- Arabi M, Ostovan A, Li J, Wang X, Zhang Z, Choo J, Chen L. 2021. Molecular imprinting: green perspectives and strategies. Adv Mater, 33: 2100543.
- Baydemir G, Bereli N, Andaç M, Say R, Galaev IY, Denizli A. 2009. Bilirubin recognition via molecularly imprinted supermacroporous cryogels. Colloids Surf B: Biointerfaces, 68: 33-38.
- BelBruno JJ. 2018. Molecularly imprinted polymers. Chem Rev, 119: 94-119.
- Chang H, Chang Y, Lai S, Chen K, Wang K, Chiu T, Chang F, Hsu L. 2017. Naringenin inhibits migration of lung cancer cells via the inhibition of matrix metalloproteinases-2 and-9. Exp Therap Medic, 13: 739-744.
- Choudhury R, Chowrimootoo G, Srai K, Debnam E, Rice-Evans CA. 1999. Interactions of the flavonoid naringenin in the gastrointestinal tract and the influence of glycosylation. Biochem Biophysic Res Commun, 265: 410-415.
- Cordenonsi LM, Bromberger NG, Raffin RP, Scherman EE. 2016. Simultaneous separation and sensitive detection of naringin and naringenin in nanoparticles by chromatographic method indicating stability and photodegradation kinetics. Biomed Chromatog, 30: 155-162.
- Dikici E, Acet BÖ, Acet Ö, Odabaşi M. 2023. “Lab-on-pol” colormatic sensor platforms: Melamine detection with color change on melamine imprinted membranes. Microchem J, 188: 108468.
- Ertürk G, Mattiasson B. 2014. Cryogels-versatile tools in bioseparation. J Chromatog A, 1357: 24-35.
- Haupt K, Mosbach K. 2000. Molecularly imprinted polymers and their use in biomimetic sensors. Chem Rev, 100: 2495-2504.
- Inanan T, Tüzmen N, Akgöl S, Denizli A. 2016. Selective cholesterol adsorption by molecular imprinted polymeric nanospheres and application to GIMS. Int J Biol Macromol, 92: 451-460.
- Karasu T, Özgür E, Uzun L. 2023. MIP-on-a-Chip: Artificial receptors on microfluidic platforms for biomedical applications. J Pharm Biomed Analysis, 226: 115257.
- Noori S, Tavirani MR, Deravi N, Rabbani MIM, Zarghi A. 2020. Naringenin enhances the anti-cancer effect of cyclophosphamide against MDA-MB-231 breast cancer cells via targeting the STAT3 signaling pathway. Iranian J Pharm Res, 19: 122.
- Odabaşi M, Say R, Denizli A. 2007. Molecular imprinted particles for lysozyme purification. Mater Sci Eng C, 27: 90-99.
- Patel K, Singh GK, Patel DK. 2018. A review on pharmacological and analytical aspects of naringenin. Chinese J Integrat Medic, 24: 551-560.
- Rebello CJ, Beyl RA, Lertora JJL, Greenway FL, Ravussin E, Ribnicky DM, Poulev A, Kennedy BJ, Castro HF, Campagna SR. 2020. Safety and pharmacokinetics of naringenin: A randomized, controlled, single‐ascending‐dose clinical trial. Diabet Obesity Metabol, 22: 91-98.
- Sant A, Ahmad I, Bhatia S. 2022. Extraction and Hydrolysis of Naringin from Citrus fruit peels. IOP Conf Ser: Mate Sci Eng, 1263: 12031.
- Stabrauskiene J, Kopustinskiene DM, Lazauskas R, Bernatoniene J. 2022. Naringin and naringenin: Their mechanisms of action and the potential anticancer activities. Biomedicines, 10: 1686.
- Trotta F, Drioli E, Baggiani C, Lacopo D. 2002. Molecular imprinted polymeric membrane for naringin recognition. J Membrane Sci, 201: 77-84.
- Wackerlig J, Schirhagl R. 2016. Applications of molecularly imprinted polymer nanoparticles and their advances toward industrial use: a review. Analyt Chem, 88: 250-261.
Öz
Naringenin is a flavanone of the flavonoid class with significant therapeutic effects. It is thought that naringenin, a compound that has been studied extensively abroad, has not received much attention in our country. Naringenin imprinted cryogels were synthesized using a new method, molecular imprinting, to draw attention to this molecule of naringenin, which is commonly found in plants. Along with characterization studies such as elemental analysis, thermogravimetric analysis and swelling tests, adsorption and selectivity tests were also carried out. Some of the findings are summarized below: The degradation temperature of naringenin in imprinted polymers increased by 1.7 °C. The amount of naringenin in MIP was found to be 16.36% higher than in the NIP. Swelling values for MIP and NIP were calculated as 850% 967%, respectively.
Anahtar Kelimeler
Naringenin Molecularly imprinted polymer Naringe purification
Proje Numarası
121Z173
Kaynakça
- Acet Ö, Noma SAA, Acet BÖ, Dikici E, Osman B. Odabaşı M. 2023. A rational approach for 3D recognition and removal of L-asparagine via molecularly imprinted membranes. J Pharmac Biomedic Analysis, 226: 115250.
- Acet Ö, Odabaşı M. 2022. Detection of N-hexanoyl-L-homoserine lactone via MIP-based QCM sensor: preparation and characterization. Polymer Bul, 80: 6657-6674.
- Arabi M, Ostovan A, Li J, Wang X, Zhang Z, Choo J, Chen L. 2021. Molecular imprinting: green perspectives and strategies. Adv Mater, 33: 2100543.
- Baydemir G, Bereli N, Andaç M, Say R, Galaev IY, Denizli A. 2009. Bilirubin recognition via molecularly imprinted supermacroporous cryogels. Colloids Surf B: Biointerfaces, 68: 33-38.
- BelBruno JJ. 2018. Molecularly imprinted polymers. Chem Rev, 119: 94-119.
- Chang H, Chang Y, Lai S, Chen K, Wang K, Chiu T, Chang F, Hsu L. 2017. Naringenin inhibits migration of lung cancer cells via the inhibition of matrix metalloproteinases-2 and-9. Exp Therap Medic, 13: 739-744.
- Choudhury R, Chowrimootoo G, Srai K, Debnam E, Rice-Evans CA. 1999. Interactions of the flavonoid naringenin in the gastrointestinal tract and the influence of glycosylation. Biochem Biophysic Res Commun, 265: 410-415.
- Cordenonsi LM, Bromberger NG, Raffin RP, Scherman EE. 2016. Simultaneous separation and sensitive detection of naringin and naringenin in nanoparticles by chromatographic method indicating stability and photodegradation kinetics. Biomed Chromatog, 30: 155-162.
- Dikici E, Acet BÖ, Acet Ö, Odabaşi M. 2023. “Lab-on-pol” colormatic sensor platforms: Melamine detection with color change on melamine imprinted membranes. Microchem J, 188: 108468.
- Ertürk G, Mattiasson B. 2014. Cryogels-versatile tools in bioseparation. J Chromatog A, 1357: 24-35.
- Haupt K, Mosbach K. 2000. Molecularly imprinted polymers and their use in biomimetic sensors. Chem Rev, 100: 2495-2504.
- Inanan T, Tüzmen N, Akgöl S, Denizli A. 2016. Selective cholesterol adsorption by molecular imprinted polymeric nanospheres and application to GIMS. Int J Biol Macromol, 92: 451-460.
- Karasu T, Özgür E, Uzun L. 2023. MIP-on-a-Chip: Artificial receptors on microfluidic platforms for biomedical applications. J Pharm Biomed Analysis, 226: 115257.
- Noori S, Tavirani MR, Deravi N, Rabbani MIM, Zarghi A. 2020. Naringenin enhances the anti-cancer effect of cyclophosphamide against MDA-MB-231 breast cancer cells via targeting the STAT3 signaling pathway. Iranian J Pharm Res, 19: 122.
- Odabaşi M, Say R, Denizli A. 2007. Molecular imprinted particles for lysozyme purification. Mater Sci Eng C, 27: 90-99.
- Patel K, Singh GK, Patel DK. 2018. A review on pharmacological and analytical aspects of naringenin. Chinese J Integrat Medic, 24: 551-560.
- Rebello CJ, Beyl RA, Lertora JJL, Greenway FL, Ravussin E, Ribnicky DM, Poulev A, Kennedy BJ, Castro HF, Campagna SR. 2020. Safety and pharmacokinetics of naringenin: A randomized, controlled, single‐ascending‐dose clinical trial. Diabet Obesity Metabol, 22: 91-98.
- Sant A, Ahmad I, Bhatia S. 2022. Extraction and Hydrolysis of Naringin from Citrus fruit peels. IOP Conf Ser: Mate Sci Eng, 1263: 12031.
- Stabrauskiene J, Kopustinskiene DM, Lazauskas R, Bernatoniene J. 2022. Naringin and naringenin: Their mechanisms of action and the potential anticancer activities. Biomedicines, 10: 1686.
- Trotta F, Drioli E, Baggiani C, Lacopo D. 2002. Molecular imprinted polymeric membrane for naringin recognition. J Membrane Sci, 201: 77-84.
- Wackerlig J, Schirhagl R. 2016. Applications of molecularly imprinted polymer nanoparticles and their advances toward industrial use: a review. Analyt Chem, 88: 250-261.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Mühendislik |
| Bölüm | Research Articles |
| Yazarlar | |
| Proje Numarası | 121Z173 |
| Erken Görünüm Tarihi | 11 Haziran 2023 |
| Yayımlanma Tarihi | 1 Temmuz 2023 |
| Gönderilme Tarihi | 23 Mart 2023 |
| Kabul Tarihi | 10 Nisan 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 6 Sayı: 3 |
